Benoxacor is enantioselectively metabolized by rat liver subcellular fractions
نویسندگان
چکیده
منابع مشابه
Rat-Liver Mitochondria and other Subcellular Fractions
1. Rat-liver mitochondria showed a decrease in amino acid production after preparation in 0-25m-sucrose containing EDTA (lnm), but an increase in water content. When EDTA was replaced by Mn2+ (Imm) or succinate (lmM), both amino acid production and water content were lowered, whereas preparation in 0-9% potassium chloride caused an increase in both. 2. Amino acid production by rat-liver homogen...
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I. Black-hooded weanling rats were given a copper-deficient diet or diets providing 3 ppm Cu with or without supplements containing combinations of molybdate, sulphate and sulphide salts to provide 35 ppm molybdenum and z pg atoms sulphurlg. Changes in weight and blood haemoglobin concentration were studied during 48 d of treatment. The subcellular distribution of Cu and Mo in the liver was sub...
متن کاملDistribution of metals in subcellular fractions of rat liver.
The localization of various metabolic processes of cells in particulate and soluble intracellular components has been studied intensively (l-3). The effect of added metals on these processes has also received attention (4-l3), but information on the metal content of the cell fractions is limited (14-16). The association of metals with proteins has been divided into two categories on the basis o...
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The incorporation of glucosamlneJ4C into plasma lipoproteins has been measured in the intact rat, in liver slices, and in the liver microsome fraction. The labeling of lipoprotein was studied in microsome subfractions, both in viva with glucosammeJ4C and in vitro with UDP-N-acetylglucosamineW. After isolation of lipoproteins with the aid of carrier plasma, labeled lipoproteins were found in smo...
متن کاملEthosuximide is primarily metabolized by CYP3A when incubated with isolated rat liver microsomes.
The cytochrome P450 (CYP) subfamily responsible for ethosuximide metabolism was investigated by HPLC assay of ethosuximide incubations with isolated rat liver microsomes from control rats and from rats treated with inducing agents to enrich hepatic microsomes in selected CYP isoforms. Inducing agents included beta-naphthoflavone (BNF, CYP1A inducer), phenobarbital (PB, CYP2B/2C/3A), isoniazid (...
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ژورنال
عنوان ژورنال: Chemico-Biological Interactions
سال: 2020
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2020.109247